Publications

Campos M, Govers SK, Irnov I, Dobihal GS, Cornet F, Jacobs-Wagner C (2018) Genomewide phenotypic analysis of growth, cell morphogenesis, and cell cycle events in Escherichia coli. Mol Syst Biol 25;14(6).  
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Delarue M, Brittingham GP, Pfeffer S, Surovtsev IV, Pinglay S, Kennedy KJ, Schaffer M, Gutierrez JI, Sang D, Poterewicz G, Chung JK, Plitzko JM, Groves JT, Jacobs-Wagner C, Engel BD, Holt LJ (2018) mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding. Cell 174.  
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Kim S, Jacobs-Wagner C (2018) Effects of mRNA degradation and site-specific transcriptional pausing on protein expression noise. Biophys J 114(7). pubmed pdf

Surovtsev IV, Jacobs-Wagner C (2018) Subcellular organization: A critical feature of bacterial cell replication. Cell 172(6).  
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Irnov I, Wang Z, Jannetty ND, Bustamante JA, Rhee KY, Jacobs-Wagner C (2017) Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate. PLoS Genet 13(8).  
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Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E (2017) A tick antivirulence protein potentiates antibiotics against Staphylococcus aureus. Antimicrob Agents Chemother 61(7):e00113-17.  
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Abraham NM, Liu L, Jutras BL, Yadav AK, Narasimhan S, Gopalakrishnan V, Ansari JM, Jefferson KK, Cava F, Jacobs-Wagner C, Fikrig E (2017) Pathogen-mediated manipulation of arthropod microbiota to promote infection. Proc Natl Acad Sci USA 114(5):E781-E790.  
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Arias-Cartin R, Dobihal GS, Campos M, Surovtsev IV, Parry B, Jacobs-Wagner C (2017) Replication fork passage drives asymmetric dynamics of a critical nucleoid-associated protein in Caulobacter. EMBO J 36(3):301-318.  
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Surovtsev IV, Campos M, Jacobs-Wagner C (2016) DNA-relay mechanism is sufficient to explain ParA-dependent intracellular transport and patterning of single and multiple cargos. Proc Natl Acad Sci USA 113(46):E7268-E7276.  
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Jutras BL, Scott M, Parry B, Biboy J, Gray J, Vollmer W, Jacobs-Wagner C (2016) Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells. Proc Natl Acad Sci USA 113(33):9162-70.
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Surovtsev IV, Lim HC, Jacobs-Wagner C (2016) The slow mobility of the ParA partitioning protein underlies its steady-state patterning in Caulobacter. Biophys J 110(12):2790-9.  
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Paintdakhi A, Parry B, Campos M, Irnov I, Elf J, Surovtsev I, Jacobs-Wagner C (2016) Oufti: An integrated software package for high-accuracy, high-throughput quantitative microscopy analysis. Mol Microbiol 99(4):767-77.
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Huang F, Sirinakis G, Allgeyer ES, Schroeder LK, Duim WC, Kromann EB, Phan T, Rivera-Molina FE, Myers JR, Irnov I, Lessard M, Zhang Y, Handel MA, Jacobs-Wagner C, Lusk CP, Rothman JE, Toomre D, Booth MJ, Bewersdorf J. (2016) Ultra-High Resolution 3D Imaging of Whole Cells. Cell 166(4):1028-49. 
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Jutras BL, Jacobs-Wagner C (2015) Bacterial evolution: What goes around comes around. Curr Biol 25:R496-8. 
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Chou S, Daugherty MD, Peterson SB, Biboy J, Yang Y, Jutras BL, Fritz-Laylin LK, Ferrin MA, Harding BN, Jacobs-Wagner C, Yang XF, Vollmer W, Malik HS, Mougous JD (2015) Transferred interbacterial antagonism genes augment eukaryotic innate immune function. Nature 518: 99-101. 
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Alpha CJ, Campos M, Jacobs-Wagner C, Strobel SA (2015) Mycofumigation by the volatile organic compound producing fungus Muscodor albus induces bacterial cell death through DNA damage. Appl Environ Microbiol 81:1147-56. 
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Campos M, Surovtsev IV, Kato S, Paintdakhi A, Beltran B, Ebmeier SE, Jacobs-Wagner C (2014) A constant size extension drives bacterial cell size homeostasis. Cell 159:1433-46. 
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Lim HC, Surovtsev IV, Beltran BG, Huang F, Bewersdorf J, Jacobs-Wagner C (2014) Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation. Elife 3:e02758. 
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Deghelt M, Mullier C, Sternon JF, Francis N, Laloux G, Dotreppe D, Van der Henst C, Jacobs-Wagner C, Letesson JJ, De Bolle X (2014) G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus. Nat Commun 5:4366. 
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Parry BR, Surovtsev IV, Cabeen MT, O'Hern CS, Dufresne ER, Jacobs-Wagner C (2014) The bacterial cytoplasm has glass-like properties and is fluidized by metabolic activity. Cell 156:183-94. 
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Laloux G, Jacobs-Wagner C (2014) How do bacteria localize proteins to the cell pole? J Cell Sci 127:11-9. 
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Ko JH, Montero Llopis PM, Heinritz J, Jacobs-Waner C, Soll D (2013) Suppression of amber codons in Caulobacter crescentus by the orthogonal Escherichia coli Histidyl-tRNA synthetase/tRNAHis pair. PloS One 8:e83630.
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Fang G, Passalacqua K, Hocking J, Montero Llopis P, Gerstein M, Bergman NH, and Jacobs-Wagner C (2013) Transcriptomic and phylogenetic analysis of a bacterial cell cycle reveals strong associations between gene co-expression and evolution. BMC Genomics 14:450.
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Laloux G and Jacobs-Wagner C. (2013) Spatiotemporal control of PopZ localization through cell cycle-coupled multimerization. J Cell Biol 201:827-41.
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Takacs CN, Hocking J, Cabeen MT, Bui NK, Poggio S, Vollmer W, and Jacobs-Wagner C. (2013) Growth medium-dependent glycine incorporation into the peptidoglycan of Caulobacter crescentus. PloS One 8(2):e57579.
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Campos M and Jacobs-Wagner C. (2013) Cellular organization of the transfer of genetic information. Curr Opin Microbiol 16:171-6.
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Montero Llopis P, Sliusarenko O, Heinritz J, and Jacobs-Wagner C. (2012) In vivo biochemistry in bacterial cells using FRAP: insight into the translation cycle. Biophys J 103: 1848-59.
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Anwari K, Webb CT, Poggi S, Perry AJ, Bousoff M, Celik N, Ramm G, Lovering A, Sockett RE, Smit J, Jacobs-Wagner C, Lithgow T. (2012) The evolution of new lipoprotein subunits of the bacterial outer membrane BAM complex. Mol Microbiol 84:832-44.
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Hocking J, Priyadarshini R, Takacs NC,Costa T, Dye N, Vollmer W, and Jacobs-Wagner C. (2012) Osmolarity-dependent relocation of penicillin-binding protein PBP2 to the division machinery in Caulobacter crescentus. J Bacteriol 194:3116-27.
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Charbon G, Wang J, Brustad E, Schultz PG, Horwich , Jacobs-Wagner C, Chapman E. (2011) Localization of GroEL determined by in vivo incorporation of fluorescent amino acid. Bioorg Med Chem Lett 211:6067-70.
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Charbon G, Brustad E, Scott KA, Wang J, Løbner-Olesen A, Schultz PG, Jacobs-Wagner C, Chapman E. (2011) Subcellular protein localization by using a genetically encoded fluorescent amino Acid. Chembiochem 12:1818-21.
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Sliusarenko O, Heinritz J, Emonet T, Jacobs-Wagner C. (2011) High-throughput, subpixel precision analysis of bacterial morphogenesis and intracellular spatio-temporal dynamics. Mol Microbiol; 80:612-27.
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Cabeen MT, Herrmann H, Jacobs-Wagner C. (2011) The domain organization of the bacterial intermediate filament-like protein crescentin is important for assembly and function. Cytoskeleton (Hoboken); 68:205-19.
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Cabeen MT, Jacobs-Wagner C. (2010) The bacterial cytoskeleton. Annu Rev Genet; 44:365-92.
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Schofield WB, Lim HC, Jacobs-Wagner C. (2010) Cell cycle coordination and regulation of bacterial chromosome segregation dynamics by polarly localized proteins. EMBO J; 29:3068-81.
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Cabeen MT, Jacobs-Wagner C. (2010) A metabolic assembly line in bacteria. Nat Cell Biol; 12:731-3.
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Montero Llopis PM, Jackson AF, Sliusarenko O, Surovtsev I, Heinritz J, Emonet T, Jacobs-Wagner C. (2010) Spatial organization of the flow of genetic information in bacteria. Nature; 466: 77-81.
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Poggio S, Takacs CN, Vollmer W, Jacobs-Wagner C. (2010) A protein critical for cell constriction in the Gram-negative bacterium Caulobacter crescentus localizes at the division site through its peptidoglycan-binding LysM domains. Mol Microbiol; 77:74-89
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Cabeen MT, Murolo MA, Briegel A, Bui NK, Vollmer W, Ausmees N, Jensen GJ, Jacobs-Wagner C. (2010) Mutations in the Lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus. J Bacteriol;192: 3368-78. 

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Sliusarenko O, Cabeen MT, Wolgemuth CW, Jacobs-Wagner C, Emonet T. (2010) Processivity of peptidoglycan synthesis provides a built-in mechanism for the robustness of straight-rod cell morphology. Proc Natl Acad Sci U S A;107: 10086-91. 
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Anwari K, Poggio S, Perry A, Gatsos X, Ramarathinam SH, Williamson NA, Noinaj N, Buchanan S, Gabriel K, Purcell AW, Jacobs-Wagner C, Lithgow T. (2010) A modular BAM complex in the outer membrane of the alpha-proteobacterium Caulobacter crescentus. PLoS One 5, e8619.
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Takacs CN, Poggio S, Charbon G, Pucheault M, Vollmer W, Jacobs-Wagner C. (2010) MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall.
J Bacteriol. 192, 1671-84.
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Angelastro PS, Sliusarenko O, Jacobs-Wagner C. (2010) Polar localization of the CckA histidine kinase and cell cycle periodicity of the essential master regulator CtrA in Caulobacter crescentus. J Bacteriol. 192, 539-52.
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Clements A, Bursac D, Gatsos X, Perry AJ, Civciristov S, Celik N, Likic VA, Poggio S, Jacobs-Wagner C, Strugnell RA, Lithgow T. (2009) The reducible complexity of a mitochondrial molecular machine. Proc Natl Acad Sci U S A. 106, 15791-5.
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Cabeen MT, Charbon G, Vollmer W, Born P, Ausmees A, Weibel, D and Jacobs-Wagner C. (2009) Bacterial cell curvature via mechanical control of cell growth. EMBO J 28, 1208-1219.
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Charbon G, Cabeen MT and Jacobs-Wagner C. (2009) Bacterial intermediate filaments: In vivo assembly, organization and dynamics of crescentin. Genes & Dev 23, 1131-44.
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Alyahya S.A, Alexander A, Costa T, Henriques AO, Emonet T, Jacobs-Wagner C. (2009) RodZ, a component of the bacterial core morphogenic apparatus. Proc Natl Acad Sci USA 106:1239-44.

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Costa T, Priyadarshini R, Jacobs-Wagner C. (2008) Localization of PBP3 in Caulobacter crescentus is highly dynamic and largely relies on its functional transpeptidase domain. Mol Microbiol. 70:634-651.
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Ebersbach G, Briegel A, Jensen GJ, Jacobs-Wagner C. (2008) A self-associating protein critical for chromosome attachment, division, and polar organization in Caulobacter. Cell 134:956-68.
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Obuchowski PL, Jacobs-Wagner C. (2008) PflI, a protein involved in flagellar positioning in Caulobacter crescentus.
J Bacteriol. 190:1718-29.
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Cabeen MT, Jacobs-Wagner C. (2007) Skin and bones: the bacterial cytoskeleton, cell wall, and cell morphogenesis.
J Cell Biol. 179:381-7.
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Aaron M, Charbon G, Lam H, Schwarz H, Vollmer W, Jacobs-Wagner C. (2007) The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentusMol Microbiol. 64:938-52.

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Hallez R, Mignolet J, Van Mullem V, Wery M, Vandenhaute J, Letesson JJ, Jacobs-Wagner C, De Bolle X. (2007) The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus. EMBO J. 26:1444-55.
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Ebersbach G, Jacobs-Wagner C. (2007) Exploration into the spatial and temporal mechanisms of bacterial polarity. Trends Microbiol. 15:101-8.
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Lam H., Schofield W.B. and Jacobs-Wagner, C. (2006) A landmark protein essential for establishing and perpetuating the polarity of a bacterial cell. Cell124:1011-23.
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Cabeen, M.T. and Jacobs-Wagner, C. (2005) Bacterial cell shape. Nat Rev Microbiol. 3:601-10
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Matroule J.Y., Lam H., Burnette D.T., and Jacobs-Wagner C. (2004) Cytokinesis monitoring during development: Rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in Caulobacter. Cell 118: 579-90. 
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Jacobs-Wagner, C. (2004) Regulatory proteins with a sense of direction: Cell cycle signaling network in Caulobacter. Mol Microbiol. 51:7-13.
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Ausmees, N., Kuhn, J. R., and Jacobs-Wagner, C. (2003) The Bacterial cytoskeleton: An Intermediate Filament-like Function in Cell Shape. Cell 115:705-13.

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Ausmees, N. and Jacobs-Wagner, C. (2003) Spatial and temporal control of differentiation and cell cycle progression in Caulobacter crescentus. Annu Rev Microbiol. 57, 225-247.
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Lam, H., Matroule, J.-Y., and Jacobs-Wagner, C. (2003) The asymmetric spatial distribution of bacterial signal transduction proteins coordinates cell cycle events. Dev Cell 5, 149-159.
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Jacobs C, Ausmees N, Cordwell SJ, Shapiro L, Laub MT. (2003) Functions of the CckA histidine kinase in Caulobacter cell cycle control. Mol Microbiol.47:1279-90.
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